Integrase Inhibitors

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List of Anti-HIV Meds Integrase Inhibitors
What are they?

Experimental drugs are italicized, and approved drugs are in regular, non-italicized type.

Brand Name Generic Name Abbreviation Experimental Code Pharmaceutical Company
Genvoya elvitegravir + cobicistat + tenofovir AF + em ELV + COBI + TAF + FTC Gilead Sciences
Isentress raltegravir RGV MK-0518 Merck & Co
Stribild elvitegravir + cobicistat + tenofovir + emtri ELV + COBI + TDF + FTC Gilead Sciences
Tivicay dolutegravir DTG GSK-572 ViiV Healthcare
Triumeq dolutegravir + abacavir + lamivudine DTG + ABC + 3TC ViiV Healthcare
Vitekta elvitegravir ELV GS-9137 Gilead Sciences

What are Integrase Inhibitors?

In order for HIV to successfully take over a CD4 cell's machinery so that it can produce new viruses, HIV's RNA is converted into DNA by the reverse transcriptase enzyme (nucleotide/nucleoside reverse transcriptase inhibitors can block this process). After the "reverse transcription" of RNA into DNA is complete, HIV's DNA must then be incorporated into the CD4 cell's DNA. This is known as integration. As their name implies, integrase inhibitors work by blocking this process.

Integrase inhibitors may offer a lot of hope for HIV-positive people, especially those who have developed HIV resistance to drugs that target HIV's two other major enzymes: reverse transcriptase and protease.

To learn more on how HIV infects a CD4 cell and begins to create more viruses, and where each class of anti-HIV drugs blocks this process, click on the following lesson link:

HIV Life Cycle Lesson
The HIV Life Cycle (and the targets of each class of anti-HIV drugs)

Last Revised: September 24, 2014

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