A Smart + Strong Site
Subscribe to:
POZ magazine

Back to home » Treatment News » Top Stories

Most Popular Stories
Undetectable Viral Load Essentially Eliminates Transmission Risk in Straight Couples
FDA Approves New Single-Tablet HIV Regimen, Triumeq
Life Expectancy for Young People With HIV Is Nearly Normal
A 15-Year Jump in Life Expectancy for People With HIV
Scientists Devise Method of Snipping HIV From Immune Cells
Monkey HIV Vaccine Success Opens Door for Human Trials
HIV Combo Pill Less Toxic Thanks to New Form of Tenofovir
What's That Mean?
(just double-click it!)

If you don't understand one of the words in this article, just double-click it. A window will open with a definition from mondofacto's On-line Medical Dictionary. If the double-click feature doesn't work in your browser, you can enter the word below:

Most Popular Lessons
Aging & HIV
The HIV Life Cycle
Herpes Simplex Virus
Syphilis & Neurosyphilis
Treatments for Opportunistic Infections (OIs)
What is AIDS & HIV?
More News

Have medical or treatment news about HIV? Send press releases, news tips and other announcements to news@aidsmeds.com.

Click here for more news


July 2, 2013

Five-Drug Cocktail Fights HIV Reservoir During Acute Infection

Preliminary findings of a research study involving a five-drug antiretroviral (ARV) cocktail have found that people who start the therapy during acute (or very early) infection experience a marked drop in viral DNA integrated into cells when compared with those living with HIV for some time before beginning the intensified cocktail, MedPage Today reports. Eva Wolf, PhD, of MUC Research in Munich, Germany, presented these two-year results of a seven-year prospective trial at the 7th International AIDS Society (IAS) Meeting in Kuala Lumpur.

While the findings suggest that such a cocktail may help lead to a functional cure by preventing the establishment of the HIV reservoir, the study did not compare a five-drug regimen with the standard three-drug cocktail. So no conclusions can be drawn about whether five drugs would more effectively lead to a functional cure or viral remission. Recently, a study of a group known as the Visconti cohort found that 14 people with HIV in France were able to achieve viral remission after initiating ARVs during acute infection and remaining on the drugs for a median three years before terminating treatment.

The five-drug study recruited 20 participants with acute HIV infection and gave them a regimen of two nucleoside reverse transcriptase inhibitors, a protease inhibitor, the entry inhibitor Selzentry (maraviroc) and the integrase inhibitor Isentress (raltegravir). Investigators also recruited 20 people with longtime HIV infection and gave them Selzentry and Isentress in addition to their regular three-drug regimen.

Two years into the study, the chronic participants essentially had no change in their proviral DNA, which is considered to be a part of the reservoir. The primary infection group saw a median drop of 25 copies per million cells.

Experts not involved in the study criticized it for not comparing three-drug regimens with five-drug regimens and told MedPage Today that prior research has shown that an intensified drug regimen does not have a clear benefit.

To see the IAS poster, click here.

To read the MedPage Today story, click here.

Search: HIV, five-drug cocktail, antiretrovirals, ARVs, 7th International AIDS Society Meeting in Kuala Lumpur, IAS, Eva Wolf, MedPage Today, Selzentry, maraviroc, Isentress, raltegravir, proviral DNA, reservoir.

Scroll down to comment on this story.


(will display; 2-50 characters)


(will NOT display)


(will display; optional)

Comment (500 characters left):

(Note: The AIDSmeds team reviews all comments before they are posted. Please do not include ":" "@" "<" ">" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules

Show comments (0 total)

[Go to top]

Quick Links
About HIV and AIDS
The Cure
Lab Tests
Clinical Trials
HIV Meds
Starting Treatment
Switching Treatment
Drug Resistance
Side Effects
Hepatitis & HIV
Women & Children
Fact Sheets
Treatment News
Community Forums
Conference Coverage
Health Services Directory
POZ Magazine
AIDSmeds on Twitter

Conference Coverage

XX International AIDS Conference
(AIDS 2014)
Melbourne, Australia
July 20 - 25, 2014

21st Conference on Retroviruses and Opportunistic Infections
(CROI 2014)
Boston, MA
March 3 - 7, 2014

7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
(IAS 2013)
Kuala Lumpur, Malaysia
June 30 - July 3, 2013

more conference coverage

[ about AIDSmeds | AIDSmeds advisory board | our staff | advertising policy | advertise/contact us]
© 2016 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.