A Smart + Strong Site
Subscribe to:
E-newsletters
POZ magazine
JOIN AIDSMEDS YouTube

Back to home » Treatment News » Web Exclusives

Most Popular Stories
An Almost Normal Life Expectancy for People With HIV?
Undetectable Viral Load Essentially Eliminates Transmission Risk in Straight Couples
A 15-Year Jump in Life Expectancy for People With HIV
Misleading News Reports Suggest HIV Cure Is Near
New HIV Drug Class Shows Promise
Gene Therapy Shows Promise in Controlling HIV
Potential Microbicide Tricks HIV Into Sudden Death
What's That Mean?
(just double-click it!)

If you don't understand one of the words in this article, just double-click it. A window will open with a definition from mondofacto's On-line Medical Dictionary. If the double-click feature doesn't work in your browser, you can enter the word below:

Most Popular Lessons
Aging & HIV
The HIV Life Cycle
Shingles
Herpes Simplex Virus
Syphilis & Neurosyphilis
Treatments for Opportunistic Infections (OIs)
What is AIDS & HIV?
More News

Have medical or treatment news about HIV? Send press releases, news tips and other announcements to news@aidsmeds.com.

Click here for more news


emailprint

November 27, 2012

Isentress Is Effective Long-term HIV Treatment for Hepatitis Coinfection

Long-term studies have found that Isentress (raltegravir) is both safe and effective in suppressing HIV among adult patients coinfected with hepatitis B, C or both, the BusinessWire reports. Merck presented results from a post-hoc, subgroup analysis of three randomized, double-blind, Phase III clinical trials of the integrase inhibitor in both treatment-experienced (BENCHMRK-1 and -2 studies) and treatment-naive (STARTMRK study) participants at the 11th International Congress on HIV and Drug Therapy in HIV Infection in Glasgow.

The 240-week STARTMRK study involved 563 treatment-naive people with HIV receiving either Isentress or Sustiva (efavirenz), each in combination with Truvada (tenofovir/emtricitabine). Thirty-four people in the two treatment groups were coinfected with hepatitis B and/or C. In the Isentress group, five people had hepatitis C virus (HCV) and 13 hepatitis B virus (HBV).

BENCHMRK-1 and -2 were 156-week studies that included 699 treatment-experienced HIV patients with triple-class resistance who were failing HIV therapies. They received either Isentress or a placebo, each in combination with an optimized background therapy. Then, an open-label study continued after the study’s completion in which patients took Isentress with combination therapy. In the two treatment groups, 114 people were coinfected with hep B, C or both. In the Isentress arm, 27 had hepatitis C, 26 had hepatitis B and four had both hepatitis viruses.

The patients in the Isentress arm of the STARTMRK study experienced high rates of undetectable viral loads at 240 weeks: 90.9 percent of the coinfected patients and 89.1 percent of those living with just HIV. At 91.7 percent, the rate was similar for coinfected patients in the efavirenz arm, although just 80 percent of monoinfected patients maintained an undetectable viral load in that arm.

The BENCHMRK-1 and -2 trials examined undetectable viral loads at 156 weeks. In the Isentress arm, 62.3 percent of coinfected patients and 57.9 percent of monoinfected patients were undetectable. Meanwhile, the respective rates for those in the placebo arm were 14.7 percent and 26.3 percent. In the open-label extension of the study, patients who reached an undetectable viral load at 240 weeks were the following: 50 percent of coinfected patients and 52.5 percent of monoinfected patients; and in the placebo, a respective 14.7 percent and 20.5 percent.

To read the BusinessWire report, click here.



Search: Isentress, coinfection, hepatitis C, HIV, hepatitis B, viral hepattis, BusinessWire, Phase II, safe and effective, STARTMRK, BENCHMRK-1 and -2, Sustiva, efavirenze, Truvada, tenofovir, emtricitabine, HBV, HCV, viral load, 11th International Congress on HIV and Drug Therapy in HIV Infection, Glasgow.


Scroll down to comment on this story.



Name:

(will display; 2-50 characters)

Email:

(will NOT display)

City:

(will display; optional)

Comment (500 characters left):

(Note: The AIDSmeds team reviews all comments before they are posted. Please do not include ":" "@" "<" ">" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules



Show comments (0 total)


[Go to top]

Quick Links
AIDSmeds en Español
About HIV and AIDS
Lab Tests
Clinical Trials
HIV Meds
Starting Treatment
Switching Treatment
Drug Resistance
Side Effects
Disclosure
Lipodystrophy
Hepatitis & HIV
Women & Children
Fact Sheets
Treatment News
Community Forums
Blogs
Conference Coverage
Health Services Directory
POZ Magazine


    adorableone
    New York
    New York


    RyGuy00
    New York
    New York


    max38man
    Chicago
    Illinois


    thebake
    Sioux Falls
    South Dakota
Click here to join POZ Personals!
Conference Coverage

21st Conference on Retroviruses and Opportunistic Infections
(CROI 2014)
Boston, MA
March 3 - 7, 2014


7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
(IAS 2013)
Kuala Lumpur, Malaysia
June 30 - July 3, 2013


20th Conference on Retroviruses and Opportunistic Infections
(CROI 2013)
Atlanta, GA
March 3 - 7, 2013


more conference coverage

[ about AIDSmeds | AIDSmeds advisory board | our staff | advertising policy | advertise/contact us]
© 2014 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.