| Drug |
Use in Children |
Use in Newborns & Infants |
Pediatric Formulation |
| Aptivus (tipranavir) |
No dosing recommendations available. Not recommended for HIV-positive children beginning anti-HIV drug treatment for the first time. Is effective in children who have used other protease inhibitors in the past, when combined with low-dose Norvir (ritonavir). |
No dosing recommendations available. |
A liquid solution of Agenerase is available for babies and children. |
| Crixivan (indinavir) |
There is no official Crixivan dose for use in children. |
No dose available for newborns or infants. |
Not available. |
| Invirase (saquinavir) |
No dosing recommendations available. Not recommended for HIV-positive children under 16 years of age. |
No dose available for newborns or infants. |
Not available. |
| Kaletra (lopinavir + ritonavir) |
Children between the ages of 6 months and 18 years receive dosing based on either body size or body weight and depends on other HIV medications being used (Lexiva [fosamprenavir], Sustiva [efavirenz], Viracept [nelfinavir] or Viramune [nevirapine]). Although once-daily dosing is available for adults, only twice-daily dosing should be used for children. |
Kaletra can be used by infants who are between 14 days and 6 months of age. It should only be used twice a day and the dose will depend on the child's body size or body weight. It should not be combined with Lexiva, Sustiva, Viracept or Viramune in children younger than six months of age. |
A liquid formulation of Kaletra—containing 42.4 percent alcohol—is available for babies and children, which is easier to give to young children than the adult capsules. |
Lexiva
(fosamprenavir) |
Lexiva is only approved for children 2 years of age or older. Once-daily Lexiva, an option for adults, is not recommended for children (even if it is used with Norvir). There are three dosing options for children, depending on their body weight and age. |
No dosing recommendations available. |
A liquid formulation of Lexiva is available for children two years of age and older. |
Norvir
(ritonavir) |
Norvir is mostly used to boost the blood levels of other protease inhibitors. Low doses of the drug are used for this purpose. Norvir is rarely, if ever, used at its full dose to treatment HIV-positive children or adults. The Norvir dose prescribed with depend on the protease inhibitor it is being combined with, as well as the child's body size or body weight. |
Infants older than 1 month of age can take Norvir, using the dosing schedule recommended for children or the dosing specified using other protease inhibitors. |
A liquid formulation of Norvir is available for babies and children, which is easier to give to young children than the adult capsules. |
| Prezista (darunavir) |
Approved for children 3 years of age and older. Dosing is based on the child's body weight, the formulation used (pills vs. liquid) and previous treatment experience. |
No dosing recommendations available. |
A liquid formulation of Prezista is available for children, which is easier to give to young children than the adult capsules. |
| Reyataz (atazanavir) |
Only for children six years of age older. The dose of Reyataz, which should always be taken with food, will depends on the child's body weight. |
No dosing recommendations are available for children under 6 years of age. Children under the age of 3 months should never receive Reyataz due to the risk of brain damage from excess bilirubin blood levels. |
Reyataz is available in 150, 200, 250 and 300 mg capsules. |
| Viracept (nelfinavir) |
Viracept is only approved for children 2 years of age and older. The approved dose for children 2 years of age and older depends on body weight. Viracept should be taken with a meal. |
No dosing recommendations available. |
Viracept is available in a powder that can be mixed with liquid. Each gram—one level scoop—of Viracept powder contains 50 mg of the drug. |
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