A Smart + Strong Site
Subscribe to:
POZ magazine

Back to home » Treatment News » Top Stories

Most Popular Stories
Undetectable Viral Load Essentially Eliminates Transmission Risk in Straight Couples
FDA Approves New Single-Tablet HIV Regimen, Triumeq
Life Expectancy for Young People With HIV Is Nearly Normal
A 15-Year Jump in Life Expectancy for People With HIV
Scientists Devise Method of Snipping HIV From Immune Cells
Monkey HIV Vaccine Success Opens Door for Human Trials
HIV Combo Pill Less Toxic Thanks to New Form of Tenofovir
What's That Mean?
(just double-click it!)

If you don't understand one of the words in this article, just double-click it. A window will open with a definition from mondofacto's On-line Medical Dictionary. If the double-click feature doesn't work in your browser, you can enter the word below:

Most Popular Lessons
Aging & HIV
The HIV Life Cycle
Herpes Simplex Virus
Syphilis & Neurosyphilis
Treatments for Opportunistic Infections (OIs)
What is AIDS & HIV?
More News

Have medical or treatment news about HIV? Send press releases, news tips and other announcements to news@aidsmeds.com.

Click here for more news


March 18, 2013

14 French People With HIV Advance 'Functional Cure'

Following on the heels of groundbreaking news that an American baby has apparently achieved a “functional cure” of HIV comes the announcement that 14 French adults treated within two months of infection also maintain undetectable virus levels after stopping antiretroviral (ARV) therapy, MedPage Today reports. Unlike in the elusive “sterilizing cure,” in which the body would be cleared of all HIV, in a functional cure, the body can control HIV without the help of meds. As such, there is still virus in all members of the French group, although it is only detectable with highly sensitive tests. Drawing from the VISCONTI study, French researchers published their findings in the online edition of PLOS Pathogens.

All 10 men and four women who achieved the functional cure were treated during primary (also known as “acute”) infection and then remained on ARVs for between 1 and 7.6 years; the median length was 36.5 months. The individuals terminated treatment for various reasons, including the wish to take a break from ARVs and their participation in a study about treatment interruption.

The group has remained off ARVs for between 4 and 9.6 years. Eleven of them maintain viral loads below 40, and three of them below five copies. Standard viral load tests reach an undetectable reading below a level of 50, yet more sensitive single-copy assays can detect lower levels.

These 14 people were a part of a larger study group of 756 in the French database who started ARVs within six months of infection between 1997 and 2011 and stayed on therapy for at least a year.  Among those in this group who began with a detectable viral load and reached undetectable levels, 70 latter stopped their regimens and had subsequent viral load tests conducted.  Fifty-six people who made up the balance of that group of 70 did not experience viral control like the group of 14 who achieved this functional cure.  The scientists estimated that 85 percent of people treated this early would experience early viral rebound if they went of their medications.

While these findings won’t lead to immediate practical implications for HIV treatment, the researchers argue they are a proof of concept that there are circumstances in which the immune system can control the virus.

To read the MedPage Today story, click here.

To read the study click here.

Search: HIV, French, functional cure, MedPage Today, VISCONTI, PLOS Pathogens, primary infection, early, viral rebound, viral control.

Scroll down to comment on this story.


(will display; 2-50 characters)


(will NOT display)


(will display; optional)

Comment (500 characters left):

(Note: The AIDSmeds team reviews all comments before they are posted. Please do not include ":" "@" "<" ">" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules

Show comments (6 total)

[Go to top]

Quick Links
About HIV and AIDS
The Cure
Lab Tests
Clinical Trials
HIV Meds
Starting Treatment
Switching Treatment
Drug Resistance
Side Effects
Hepatitis & HIV
Women & Children
Fact Sheets
Treatment News
Community Forums
Conference Coverage
Health Services Directory
POZ Magazine
AIDSmeds on Twitter

Conference Coverage

XX International AIDS Conference
(AIDS 2014)
Melbourne, Australia
July 20 - 25, 2014

21st Conference on Retroviruses and Opportunistic Infections
(CROI 2014)
Boston, MA
March 3 - 7, 2014

7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
(IAS 2013)
Kuala Lumpur, Malaysia
June 30 - July 3, 2013

more conference coverage

[ about AIDSmeds | AIDSmeds advisory board | our staff | advertising policy | advertise/contact us]
© 2016 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.