A Smart + Strong Site
Subscribe to:
E-newsletters
POZ magazine
JOIN AIDSMEDS YouTube

Back to home » Treatment News » Top Stories

Most Popular Stories
An Almost Normal Life Expectancy for People With HIV?
Undetectable Viral Load Essentially Eliminates Transmission Risk in Straight Couples
A 15-Year Jump in Life Expectancy for People With HIV
Misleading News Reports Suggest HIV Cure Is Near
New HIV Drug Class Shows Promise
Gene Therapy Shows Promise in Controlling HIV
Potential Microbicide Tricks HIV Into Sudden Death
What's That Mean?
(just double-click it!)

If you don't understand one of the words in this article, just double-click it. A window will open with a definition from mondofacto's On-line Medical Dictionary. If the double-click feature doesn't work in your browser, you can enter the word below:

Most Popular Lessons
Aging & HIV
The HIV Life Cycle
Shingles
Herpes Simplex Virus
Syphilis & Neurosyphilis
Treatments for Opportunistic Infections (OIs)
What is AIDS & HIV?
More News

Have medical or treatment news about HIV? Send press releases, news tips and other announcements to news@aidsmeds.com.

Click here for more news


emailprint

January 28, 2013

Gilead Begins Phase III Studies of Low-Dose Prodrug Tenofovir Alafenamide

Following encouraging Phase II data announced in the fall, Gilead Sciences has begun two Phase III clinical trials of a single-tablet, once-a-day antiretroviral regimen containing tenofovir alafenamide fumarate (TAF) among treatment-naive adults.  TAF is a prodrug formulation of the active agent in Viread (tenofovir disoproxil fumarate, TDF). Prodrugs are medications that are inactive until metabolized by the body, a process that allows for lower dosing.  

Both of the new trials are randomized and double-blind and will be conducted for 96 weeks among HIV-positive participants with viral loads greater than 1,000 at the outset.  Half of the 840 people in each study will be randomized between receiving a once-a-day tablet of TAF/elvitegravir/cobicistat/emtricitabine or Gilead’s Stribild (elvitegravir/cobicistat/emtricitabine/TDF), which was approved by the U.S. Food and Drug Administration in 2012.  The study’s primary endpoint will be the proportion of participants who reach an undetectable viral load after 48 weeks of treatment. After the Phase II results showed the TAF-based combination therapy showed improved kidney and bone safety, the study will include patients with impaired kidney function and will assess bone mineral density of all participants.

“We believe that TAF’s smaller milligram size has the potential to offer safety and tolerability advantages over existing therapies, and may enable the creation of new single tablet regimens for HIV,” said Norbert Bischofberger, PhD, executive vice president of research and development and chief scientific officer at Gilead.

To read the Gilead release, click here.

Search: Gilead, HIV, Phase III, low-dose prodrug, tenofovir alafenamide fumarate, TAF, Viread, tenofovir disoproxil fumarate, TDF, Stribild, elvitegravir, cobicistat, emtricitabine, viral load, kidney, bone, Norbert Bischofberger.


Scroll down to comment on this story.



Name:

(will display; 2-50 characters)

Email:

(will NOT display)

City:

(will display; optional)

Comment (500 characters left):

(Note: The AIDSmeds team reviews all comments before they are posted. Please do not include ":" "@" "<" ">" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules



Show comments (0 total)


[Go to top]

Quick Links
AIDSmeds en Español
About HIV and AIDS
Lab Tests
Clinical Trials
HIV Meds
Starting Treatment
Switching Treatment
Drug Resistance
Side Effects
Disclosure
Lipodystrophy
Hepatitis & HIV
Women & Children
Fact Sheets
Treatment News
Community Forums
Blogs
Conference Coverage
Health Services Directory
POZ Magazine


    adoniz89
    san dimas
    California


    usuallyhappy
    Palm Springs
    California


    cortaza100
    Chicago
    Illinois


    humboman
    Baltimore
    Maryland
Click here to join POZ Personals!
Conference Coverage

21st Conference on Retroviruses and Opportunistic Infections
(CROI 2014)
Boston, MA
March 3 - 7, 2014


7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
(IAS 2013)
Kuala Lumpur, Malaysia
June 30 - July 3, 2013


20th Conference on Retroviruses and Opportunistic Infections
(CROI 2013)
Atlanta, GA
March 3 - 7, 2013


more conference coverage

[ about AIDSmeds | AIDSmeds advisory board | our staff | advertising policy | advertise/contact us]
© 2014 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.