IAS 2007 : PRO 140 Shows Promise in Single-Dose Study - by Tim Horn

A Smart + Strong Site
Subscribe to:
POZ magazine
Back to home » Top Stories » IAS 2007


PRO 140 Shows Promise in Single-Dose Study

August 1, 2007

By Tim Horn

Researchers at the fourth IAS Conference on HIV Pathogenesis, Treatment and Prevention, in Sydney, reported encouraging results from an early study of PRO 140, an experimental HIV entry inhibitor. Of particular interest was the fact that viral loads remained 90 percent below pretreatment levels two to three weeks after a single dose of the drug.

PRO 140 is a laboratory-made antibody that binds to a protein on the CCR5 membrane of CD4 cells. Once it does this, HIV cannot successfully bind with the surface of CD4s; thus the virus is prevented from infecting healthy cells.

While Pfizer’s maraviroc, which is being considered for approval by the U.S. Food and Drug Administration, works differently than PRO 140, both drugs target CCR5 and are being tested as HIV entry inhibitors.

Progenics’ clinical trial, conducted at 10 sites in the United States, examined three single intravenous doses of PRO 140: 0.5 milligram per kilogram (mg/kg) of body weight, 2.0 mg/kg and 5.0 mg/kg. A total of 39 HIV-positive patients, none of whom had used antiretrovirals in the past, were enrolled in the study.

All patients were screened prior to the study for the presence of virus that utilizes only CCR5 as its entry coreceptor (as opposed to the CXCR4 coreceptor). Of the 13 patients in each dosing group, 10 patients received PRO 140 and three received placebo.

No other HIV medications were taken in the study.

Viral load reductions were the chief focus of the study. Patients who received 5.0 mg/kg of PRO 140 achieved an average maximum viral load drop of 1.83 log, with some patients achieving viral load reductions of 2.5 log.

Ten days after receiving single-dose PRO 140, viral loads dropped by an average of 1.7 log in the 5.0 mg/kg group, compared to average reductions of 1.2 log in the 2.0 mg/kg group, 0.58 log in the 0.5 mg/kg group and 0.39 log in the placebo group. And after two to three weeks, patients who received 5.0 mg/kg PRO 140 still averaged viral loads 1.0 log below pretreatment levels.

CD4 counts increased, on average, by 129 cells in the 5.0 mg/kg PRO 140 group by day eight. The elevations in all groups persisted for approximately three weeks after the drug was administered.

Additionally, the study found PRO 140 to be generally well tolerated with no serious drug-related adverse events reported. Two of the 39 patients in the study experienced a switch in their HIV tropism, from CCR5-using virus to dual-tropic (CCR5 and CXCR4) virus.

Progenics also reported that it has developed a subcutaneous injection version of PRO 140. Based on favorable laboratory tests, the company plans to advance the subcutaneous formulation into clinical trials later this year, with the goal of developing a long-acting self-administered therapy for HIV infection.


Saag MS, Jacobson JM, Thompson M, et al. Antiviral effects and tolerability of the CCR5 monoclonal antibody PRO 140: a proof of concept study in HIV-infected individuals [Abstract WESS201]. Fourth IAS Conference on HIV Pathogenesis, Treatment and Prevention, Sydney, 2007.

[Go to top]

July 26, 2007
Beyond Condoms: Medical Approaches For Prevention
Regan Hofmann talks with Dr. Nancy Padian about PrEP, microbicides, and circumcision, and asks "when can my boyfriend and I stop using condoms."
July 25, 2007
Pipeline Preview: All The New AIDS Drugs Coming Soon
Peter Staley reviews all the new experimental AIDS drugs with Dr. Joe Eron, including two non-nukes, and two new classes of drugs: CCR5 and integrase inhibitors.
Simple Test Eliminates Abacavir Risk
Peter Staley asks Professor Simon Mallal from the Royal Perth Hospital about a simple new genetic test that accurately predicts if a patient is at risk for an allergic reaction to abacavir (Ziagen).
July 24, 2007
A Positive Papua New Guinean Speaks Out Against Stigma
Regan Hofmann interviews Maura Elaripe Mea, the first HIV-positive woman to come forward publicly in her country. Through Igat Hope, the national network of people living with HIV/AIDS in PNG, Maura and others fight AIDS discrimination while spreading information and hope.
The Latest on Lipo: Advances & Setbacks
Dr. Don Kotler discusses the latest from Sydney, both good and bad, on lipodystrophy treatments and cardiovascular risk in people with HIV.
Which HIV Meds Cause Lipoatrophy?
In this videocast, Dr. Eric Daar provides an overview of which nukes, non-nukes, and protease inhibitors might cause fat loss, and which ones probably won't.
Are We Starting Treatment Early Enough?
In this videocast, Dr. Fred Gordin explains why many experts think we might be waiting too long to put patients on HIV treatment.
July 23, 2007
An Eccentric Professor Expounds on Growing Old With HIV
A videocast interview with Professor Brian Gazzard, an expert on HIV and aging.
July 22, 2007
Fauci Defends Bush's AIDS Legacy
Peter Staley interviews Tony Fauci about his research on HIV "eradication," President Bush's AIDS legacy, why he likes gay men and Republicans, and that letter he wrote supporting Scooter Libby.

[ about AIDSmeds | AIDSmeds advisory board | our staff | advertising policy | advertise/contact us]
© 2016 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.