Two 90mg (in 1-ml solution) subcutaneous (under the skin) injections a day
Because of its fragile structure (it is a peptide), Fuzeon cannot be taken by mouth and must be injected twice a day. While there isn't a way to simplify this dosing schedule, there are ways to reduce the risk of injection-site reactions, a common side effect of Fuzeon. Read some tips in our Fuzeon lesson.
The manufacturers of Fuzeon are developing a needle-free injection equipment and are also looking at the possibility of only having to administer Fuzeon once a day. These improvements, if they prove to be safe and effective, won't likely be approved by the U.S. Food and Drug Administration until sometime in 2006.
Because of drug interactions, the dose will depend on the other medications being used at the same time as Selzentry. The correct dose will either be 150mg, 300mg or 600mg, twice a day.
At the present time, there is no simplified dosing schedule for Selzentry; it must be taken twice a day.
Selzentry is approved only for treatment-experienced HIV-positive people. While the drug is being studied in HIV-positive people beginning treatment for the first time, twice-daily dosing will still be necessary (once-daily dosing was found to be inferior in a clinical trial involving patients new to treatment).
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