November 10, 2008

Astragalus Extract May Strengthen Immune Response to HIV

An extract from a plant used in traditional Chinese medicine may help protect the genes of immune system cells and, as a result, enhance their ability to fight HIV, according to a new study announced by the University of California Los Angeles (UCLA) and published in The Journal of Immunology.

When cells reproduce, their DNA gets capped at the ends by long repeated strands of genes called telomeres. Telomeres protect the genes, much like the plastic tips on the ends of shoelaces. Unfortunately, telomeres get shorter every time a cell reproduces, which ultimately causes the cells to become “exhausted” and to stop functioning properly. This occurs naturally as a person ages, but more rapidly in the HIV-fighting CD4 and CD8 cells of people with HIV.

One of the lead researchers in telomeres and HIV, Rita Effros, PhD, and her colleague Steven Russell Fauce, PhD, of the department of pathology at UCLA, had experimented with gene therapy as a way to keep telomeres from shortening. But ultimately the researchers turned to what could potentially be a much less expensive method: an extract from the medicinal plant astragalus.

According to Effros and Fauce, the extract, TAT2, keeps an enzyme called telomerase turned on. CD4s and CD8s can naturally produce telomerase, which helps keep telomeres from shortening, but only for so long. After a cell has divided too many times, the telomerase gene turns off.

In test tube experiments, Effros and Fauce exposed CD4 and CD8 cells collected from HIV-positive patients to TAT2. Not only did the substance slow the shortening of the cells’ telomeres, but it also increased the cells’ production of proteins known to inhibit HIV replication.

While studies of TAT2 have not yet been conducted in people, the authors believe the strategy “could be useful in treating HIV disease, as well as immunodeficiency and increased susceptibility to other viral infections associated with chronic diseases or aging.”

Search: Astragalus, TAT2, Rita Effros, Steven Russel Fauce, UCLA, telomeres, telomerase, DNA

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Previous Comments:

Mac Osmer, Pine Bluff AR 71603, 2009-01-28 22:17:34
"Unfortunately, telomeres get shorter every time a cell reproduces, which ultimately causes the cells to become “exhausted” and to stop functioning properly. This occurs naturally as a person ages, but more rapidly in the HIV-fighting CD4 and CD8 cells of people with HIV". Based on your statement, quoted above, how long will TAT2 extend the life of an 84 yr old? Also, will astragalus root, sold by health food stores, have the same anti-aging effect?

BgM, Savannah, 2008-11-16 10:55:50
Finally....I have been using astragalus for several years, along with a few other herbal suppliments, after researching its CD8 & CD4 enhancement properties. I am now my doctors longest living patient. Something must be working.

Steve, Morristown, 2008-11-12 13:39:30
I'm a firm believer in giving my body ANY ability to fight/lower/get rid of hiv by natural means (along with my current ARV regimen), so it would be excellent if studies WERE conducted as soon as possible on people to see if this could be taken with (to compliment and boost), my current meds. Where do I sign up?

tomg, atlanta, 2008-11-11 11:02:35
finally we were using this in the early 80's and finally someone says something about it here i am poz like 26 yrs.