A Smart + Strong Site
Subscribe to:
POZ magazine

Back to home » Treatment News » Top Stories

Most Popular Stories
Undetectable Viral Load Essentially Eliminates Transmission Risk in Straight Couples
FDA Approves New Single-Tablet HIV Regimen, Triumeq
Life Expectancy for Young People With HIV Is Nearly Normal
A 15-Year Jump in Life Expectancy for People With HIV
Scientists Devise Method of Snipping HIV From Immune Cells
Monkey HIV Vaccine Success Opens Door for Human Trials
HIV Combo Pill Less Toxic Thanks to New Form of Tenofovir
What's That Mean?
(just double-click it!)

If you don't understand one of the words in this article, just double-click it. A window will open with a definition from mondofacto's On-line Medical Dictionary. If the double-click feature doesn't work in your browser, you can enter the word below:

Most Popular Lessons
Aging & HIV
The HIV Life Cycle
Herpes Simplex Virus
Syphilis & Neurosyphilis
Treatments for Opportunistic Infections (OIs)
What is AIDS & HIV?
More News

Have medical or treatment news about HIV? Send press releases, news tips and other announcements to news@aidsmeds.com.

Click here for more news


February 13, 2013

Tenofovir May Raise Risk of Kidney Damage, but Effect Tapers Over Time

The commonly prescribed antiretroviral (ARV) tenofovir raises the risk of kidney dysfunction among people with HIV, but the adverse effect occurs mostly within the first two years after beginning the therapy and then tapers in the years following.  Furthermore, it appears that while tenofovir may increase the risk of renal damage, the actual effect in terms of a rise in cases of kidney disease may prove modest. Following on the heels of other research studies that have identified tenofovir’s adverse effects on the kidneys, Canadian researchers looked to establish the magnitude of the effect; they published their findings in the journal Clinical Infectious Diseases.  

The active ingredient in Viread (tenofovir disoproxil fumarate) and a component of Atripla (efavirenz/emtricitabine/tenofovir), tenofovir is currently prescribed to about half of all people with HIV taking antiretrovirals.

The non-randomized study included 1,043 people with HIV taking tenofovir, who were followed up for 10 years; it examined the loss in what is known as the glomerular filtration rate (eGFR), an indicator of kidney function. Researchers compared the cohort’s eGFR to people with HIV who were exposed to other ARVs.

The study found that tenofovir increased the risk of kidney dysfunction by 63 percent and that the drop in eGFR was weighted toward the first two years. The respective eGFR, measured in mL/min/1.73 m2, for years 1, 2, 3 and 4 was -3.05, -4.05, -2.42 and -3.09.  

The findings are buffered by the study’s size as well as the long follow-up period. However, the researchers were not able to effectively speculate the drop in eGFR beyond year four of exposure to tenofovir.

The study’s authors write, “Our study shows that the association was not of a high magnitude and that the quantified loss in eGFR attributable to [tenofovir] is relatively modest after many years of exposure…. [I]t is highly plausible that [tenofovir] exposure, although associated with reduced kidney function, has no severe adverse effects over the long term for most HIV-positive patients.”

To read the study, click here.

Search: tenofovir, HIV, kidney damage, antiretroviral, ARV, renal, Clinical Infectious Diseases, tenofovir disoproxil fumarate, Viread, Atripla, efavirenz, emtricitabine, glomerular filtration rate, eGFR.

Scroll down to comment on this story.


(will display; 2-50 characters)


(will NOT display)


(will display; optional)

Comment (500 characters left):

(Note: The AIDSmeds team reviews all comments before they are posted. Please do not include ":" "@" "<" ">" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules

Show comments (2 total)

[Go to top]

Quick Links
About HIV and AIDS
The Cure
Lab Tests
Clinical Trials
HIV Meds
Starting Treatment
Switching Treatment
Drug Resistance
Side Effects
Hepatitis & HIV
Women & Children
Fact Sheets
Treatment News
Community Forums
Conference Coverage
Health Services Directory
POZ Magazine
AIDSmeds on Twitter

Conference Coverage

XX International AIDS Conference
(AIDS 2014)
Melbourne, Australia
July 20 - 25, 2014

21st Conference on Retroviruses and Opportunistic Infections
(CROI 2014)
Boston, MA
March 3 - 7, 2014

7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
(IAS 2013)
Kuala Lumpur, Malaysia
June 30 - July 3, 2013

more conference coverage

[ about AIDSmeds | AIDSmeds advisory board | our staff | advertising policy | advertise/contact us]
© 2016 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.